Unsuspected Involvement of Spinal Cord in Alzheimer Disease

Lorenzi, Roberta Maria and Palesi, Fulvia and Castellazzi, Gloria and Vitali, Paolo and Anzalone, Nicoletta and Bernini, Sara and Cotta Ramusino, Matteo and Sinforiani, Elena and Micieli, Giuseppe and Costa, Alfredo and D’Angelo, Egidio and Gandini Wheeler-Kingshott, Claudia A. M. (2020) Unsuspected Involvement of Spinal Cord in Alzheimer Disease. Frontiers in Cellular Neuroscience, 14. ISSN 1662-5102

[thumbnail of pubmed-zip/versions/1/package-entries/fncel-14-00006/fncel-14-00006.pdf] Text
pubmed-zip/versions/1/package-entries/fncel-14-00006/fncel-14-00006.pdf - Published Version

Download (2MB)

Abstract

Objective: Brain atrophy is an established biomarker for dementia, yet spinal cord involvement has not been investigated to date. As the spinal cord is relaying sensorimotor control signals from the cortex to the peripheral nervous system and vice-versa, it is indeed a very interesting question to assess whether it is affected by atrophy due to a disease that is known for its involvement of cognitive domains first and foremost, with motor symptoms being clinically assessed too. We, therefore, hypothesize that in Alzheimer’s disease (AD), severe atrophy can affect the spinal cord too and that spinal cord atrophy is indeed an important in vivo imaging biomarker contributing to understanding neurodegeneration associated with dementia.

Item Type: Article
Subjects: Library Keep > Medical Science
Depositing User: Unnamed user with email support@librarykeep.com
Date Deposited: 26 May 2023 07:23
Last Modified: 20 Jan 2024 10:50
URI: http://archive.jibiology.com/id/eprint/931

Actions (login required)

View Item
View Item