The Role of Transcription Factors in Cytokine-Mediated Apoptosis of Lymphocytes

Saveleva, Olga Evgenevna and Litvinova, Larisa Sergeevna and Anishchenko, Evgeniya Sergeevna and Novitsky, Viacheslav Viktorovish and Riazantseva, Nataliya Vladimirovna (2011) The Role of Transcription Factors in Cytokine-Mediated Apoptosis of Lymphocytes. International Journal of Biology, 4 (1). pp. 129-137. ISSN 1916-9671

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Official URL: https://doi.org/10.5539/ijb.v4n1p129

Abstract

The role of transcription factors in the implementation of IL-2 and IL-4 proapoptotic effects investigated in the in vitro experiment. It is shown that recombinant IL-2 at a dose of 0.10 ng/ml and IL-4 at a dose of 0.15 ng/ml have apoptotic effects on lymphocytes. At the apoptosis induction by rIL-2 and rIL-4 the transcription factors NF-kB, p53, pRb and inhibitor of cyclin-dependent kinases p21WAF1/CIP1 are activated.

Item Type:	Article
Subjects:	Library Keep > Biological Science
Depositing User:	Unnamed user with email support@librarykeep.com
Date Deposited:	24 May 2023 07:28
Last Modified:	29 Jan 2024 06:23
URI:	http://archive.jibiology.com/id/eprint/927

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