Ameliorating Potential of Honey on Caffeine Induced Sperm Toxicity in Male Albino Rats

This study evaluated the ameliorating effect of honey on caffeine-induced sperm toxicity in male albino rats. Thirty healthy male albino rats of 12 weeks old were divided into five groups with six rats in each group using a Completely Randomized Design (CRD). The experimental animals were treated with combinations of caffeine and honey orally. Group 1 served as the control and was given only water and feed; Group 2 (honey group) received 10 ml/kgBW of honey; Group 3 (caffeine group) received 200 mg/kgBW of caffeine; Group 4 (C + H1 group) received 200 mg/kgBW of caffeine and 10 ml/kgBW of honey while Group 5 (C + H2) received 20 ml/kgBW of honey and 200 mg/kgBW of caffeine. The treatments lasted for a period of 65 days. Results showed statistically significant (p<0.05) reduction in weight of testes and epididymis, epididymal sperm viability, motility and count in caffeine treated rats when compared with the control. There was a concomitant increase in sperm head abnormalities in caffeine treated rats. However, honey effectively ameliorated the caffeine induced sperm toxicities in albino rat models in a dose-dependent manner.