Improvement of fertility outcomes using dexamethasone / antibiotic adjuvant therapy following hysterosalpingography in infertile females: A randomised trial

Objectives: To evaluate the benefit of modified hydrotubation with dexamethasone and antibiotics after hysterosalpingography in improving pregnancy rates in women with infertility issue.

Methods: This retrospective study conducted at County Emergency Clinical Hospital Oradea, Bihor, Romania, between January 2017 and December 2019. One hundred twenty infertile females were investigated, as part of their evaluation, Hysterosalpingography was performed. After the investigation 97 patients had taken utero-tubal instillations with (Ceftriaxone 1 gr. [Cefort] and 4 mg of Dexamethasone, Lidocaine 1% 10 ml, and a Sodium chloride 0.9% 10 ml), and 23 patients were included in the control group which didn’t receive utero-tubal instillations. Number of obtained pregnancies by natural way over the next year was compared in the two groups.

Results: From all participants in this study, 30 women became pregnant during the study. In addition, 29 out of 30 pregnant women had taken hydrotubation procedure. The significant statistical difference was observed between the groups p=0.011 (p<0.05), and the odd ratio was less than one (OR=9.3, 95%, CI:1,207 to 72.926). We also found an indirect correlation between abortion in the past and the pregnancy ratio (r=-0.21).

Conclusion: The results of the study demonstrated that the application of modified hydrotubation with the administration of dexamethasone and antibiotics in patients who had at least one patent fallopian tubes, can increase the chance of fertility.