COSTUS AFER JUICE EXTRACT EFFECT ON SOME ANTIOXIDANT AND LIVER MARKERS OF TESTOSTERONE PROPIONATE INDUCED PROSTATITIS IN WISTAR RATS

The curative potentials of Costus afer on testosterone induced prostatitis and some biochemical parameters was investigated using rat models. Eighteen (18) male wistar rats were used. The rats were weighed and randomly separated into six (6) groups of 3 rats each and were induced with testosterone propionate (TP). The reference drug Centiflo XL (400mg) was used. Group I was not induced which served as control while group II rats were induced with TP without treatment. Group III rats were induced with TP and administered the standard drug. Group IV, V and VI were given the whole extract (100ml, 200ml and 300ml respectively). The administration, feeding, and housing lasted for twenty-eight (28) days. Qualitative phytochemical analysis of Costus afer revealed the presence of Flavonoids, Saponins, Phenols, Alkaloids, Cardiac Glycosides and the absence of Tanins. Results obtained show that the rats in group IV, V, and VI which were given Costus afer extract at different concentrations had decreased Prostrate specific antigen (PSA), testosterone, and Alkaline Phospatase (ALP) levels, while stress enzyme levels, Aspartate transaminase (AST) and Alanine transaminase (ALT) levels were elevated due to the presence of phenolic compounds in the whole extract of Costus afer. From this study, it can be said that the whole extract of Costus afer could be recommended as an effective drug in the treatment/management of Prostatitis.