STAT3 Mutations, Parasitic Infection and the IL-17 Pathway

Parasitic infections may be commonly found in global distribution in endemic areas. Parasitic
infections are associated with a serum IgE response and peripheral eosinophilia. Strongyloides and
Ascaris infections are examples of parasitic infections and pulmonary disease. The combined
presence of parasitic infections and high immunoglobulin level E (IgE) levels can be found in isolation
or as a clinical manifestation of certain immune defects.
The Hyper-IgE syndromes (HIES) as a group of distinct primary immune disorders should be
considered in the differential and treatment of parasitic disease. The aim of this study was to highlight
the importance of recognizing underlying immune defects in the clinical setting of parasitic infection,
including HIES.