4-N-(7-Chloroquinolin-4-yl)-1-N,1-N-diethyl petane-1,4-diamine Ti Complex: Synthesis and Characterization

Aims: Chloroquine is a member of the drug class 4-aminoquinoline used for the prevention and treatment of malaria in areas where malaria is known to be sensitive to its effects. Most metals are capable of forming covalent bonds with carbon, resulting in metal-organic compounds.

Our aim is to synthesize the chloroquine – titanium complex and to study its coordination behavior. Place and Duration of Study: Department of Chemistry, Michael Okpara University of Agriculture, Umudike, 2019.

Methodology: Ti(II) complex of chloroquine was synthesized by the reaction of chloroquine phosphate with titanium(IV) oxide. The metal complex was characterized based on UV, IR and 1H NMR Spectroscopy.

Results: The UV spectrum of the complex suggested intra ligand charge transfer (ILCT), ligand to metal charge transfer (LMCT), and d-d transition. The IR spectrum of the complex showed the involvement of amine and imine group in coordination to Ti. This showed that chloroquine acted as a bidentate ligand. 1H NMR of the spectrum further showed the involvement of the amine group in coordination.

Conclusion: The ability of chloroquine to sequestrate Ti (II) ion has been assured. This drug can be used to chelate Ti ions from solution, environment, and biological system.