Evaluation of Serum Prolactin and Testosterone in Premature Ejaculation Patients

Background Premature ejaculation is a frequently encountered sexual dysfunction in men. It significantly impairs quality of life of the affected male and his partner. This study investigated the role of hormonal factors (prolactin and testosterone) in patients with premature ejaculation.

Objectives: evaluating the contribution of prolactin and testosterone in the pathogenesis of premature ejaculation.

Methods: A group of 26 patients suffering from premature ejaculation;15 of them presented with primary type, and 11 of them complained of secondary type. Another group of 10 subjects served as a control group. All the individuals were subjected to clinical evaluation, and venous blood samples for laboratory investigation of serum prolactin and total testosterone.

Results: Comparing the serum prolactin levels between all groups showed no significant statistical differences (p:>0.05). While the levels of total serum testosterone were significantly lower in the primary premature ejaculation patients than in the control group and were more lower in the secondary premature ejaculation patients than both the control and primary type patients (p:<0.05).

Conclusion: It is recommended to routinely investigate testosterone serum levels in secondary premature ejaculation patients, especially that is thought to be a high-risk factor in secondary type.