A Case Study on Metaplastic Carcinoma of the Breast with Mesenchymal Differentiation

Metaplastic carcinomas, which represent less than 1% of breast carcinomas, are a heterogeneous group of carcinomas with mesenchymal or squamous differentiation. In some cases, evidence of ductal differentiation is entirely lacking and the tumor is composed exclusively of squamous or sarcomatoid elements. Some tumors can be cystic. We would like to describe a case of a 56-year-old woman who visited our OPD complaining of a firm tumor in her right breast. She has no first-degree relatives with a H/o of breast cancer. She had a painful lump in her right breast that had been there for the previous six months and had progressively become bigger. There are no other risk factors or a history of comparable symptoms in other family members. The efforts to maintain sufficient data and evidence to establish a reliable treatment strategy in this unanticipated breast neoplasm have been frustrated by the rarity and heterogeneity of MBC in biological and morphological features as well as by different classification and treatment strategies in the literature. A greater effort should be made to identify potential molecular targets, and more trials should be carried out in order to move beyond small series and evaluate the efficacy of targeted therapies. Although encouraging results in small, carefully chosen patient groups who were treated in accordance with cancer stem cell characteristics have been observed, these results should not be taken as a guarantee.